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DNA Cell Biol 33(2):102109 Rida MA, Gladman DD (2020) Case report of refractory psoriatic arthritis achieving remission using Nigella sativa (black seed oil) extract

Lipotropic Agents Lipotropic agents, such as methionine, inositol, and choline, are combined with vitamin B12 in Lipo B12 shots to enhance fat metabolism and support liver health

Notably, autophagy dysfunction and metabolic disturbances form a vicious cycle - impaired autophagic flux exacerbates glucose and lipid metabolic imbalances (Kim and Lee, 2014), which may serve as a key driver for the progressive metabolic deterioration in DM (Figure 3)